Asynchronous spiking neurons, the natural key to exploit temporal sparsity

Inference of Deep Neural Networks for stream signal (Video/Audio) processing in edge devices is still challenging. Unlike the most state of the art inference engines which are efficient for static signals, our brain is optimized for real-time dynamic signal processing. We believe one important feature of the brain (asynchronous state-full processing) is the key to its excellence in this domain. In this work, we show how asynchronous processing with state-full neurons allows exploitation of the existing sparsity in natural signals. This paper explains three different types of sparsity and proposes an inference algorithm which exploits all types of sparsities in the execution of already trained networks. Our experiments in three different applications (Handwritten digit recognition, Autonomous Steering and Hand-Gesture recognition) show that this model of inference reduces the number of required operations for sparse input data by a factor of one to two orders of magnitudes. Additionally, due to fully asynchronous processing this type of inference can be run on fully distributed and scalable neuromorphic hardware platforms

Doença de chagas: tendência epidemiológica por regiões do Brasil / Chagas disease: epidemiological trend by regions of Brazil

A doença de Chagas é uma condição crônica negligenciada com elevada carga de morbimortalidade, no período de 2000 a 2013 foram notificados 1.570 casos de doença de Chagas aguda . Trata-se de um estudo transversal de caráter descritivo, teve como população os casos de notificados doença de chagas aguda dos últimos anos disponíveis do DATASUS,foram dos anos 2013 a 2014 no Brasil. Os dados obtidos foram coletados do DATASUS nas informações de saúde (TABNET). O total de 191 de notificações de doença de chagas aguda no anos de 2014 no Brasil. Os dados epidemiológicos demonstram a necessidade de se aumentar à vigilância na região Norte e incorporar indicadores ambientais para a detecção precoce e prevenção de agravos à saúde da população em relação a doença de chagas

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial

Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.Hospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of Healt

DHyANA : uma arquitetura digital neuromórfica hierárquica para máquinas de estado líquido

Neural Networks has been a subject of research for at least sixty years. From the effectiveness in processing information to the amazing ability of tolerating faults, there are countless processing mechanisms in the brain that fascinates us. Thereupon, it comes with no surprise that as enabling technologies have become available, scientists and engineers have raised the efforts to understand, simulate and mimic parts of it. In a similar approach to that of the Human Genome Project, the quest for innovative technologies within the field has given birth to billion dollar projects and global efforts, what some call a global blossom of neuroscience research. Advances in hardware have made the simulation of millions or even billions of neurons possible. However, existing approaches cannot yet provide the even more dense interconnect for the massive number of neurons and synapses required. In this regard, this work proposes DHyANA (Digital HierArchical Neuromorphic Architecture), a new hardware architecture for a spiking neural network using hierarchical network-on-chip communication. The architecture is optimized for Liquid State Machine (LSM) implementations. DHyANA was exhaustively tested in simulation platforms, as well as implemented in an Altera Stratix IV FPGA. Furthermore, a logic synthesis analysis using 65-nm CMOS technology was performed in order to evaluate and better compare the resulting system with similar designs, achieving an area of 0.23mm2 and a power dissipation of 147mW for a 256 neurons implementation.Redes Neurais têm sido um tema de pesquisas por pelo menos sessenta anos. Desde a eficácia no processamento de informações à incrível capacidade de tolerar falhas, são incontáveis os mecanismos no cérebro que nos fascinam. Assim, não é nenhuma surpresa que, na medida que tecnologias facilitadoras tornam-se disponíveis, cientistas e engenheiros têm aumentado os esforços para o compreender e simular. Em uma abordagem semelhante à do Projeto Genoma Humano, a busca por tecnologias inovadoras na área deu origem a projetos internacionais que custam bilhões de dólares, o que alguns denominam o despertar global de pesquisa da neurociência. Avanços em hardware fizeram a simulação de milhões ou até bilhões de neurônios possível. No entanto, as abordagens existentes ainda não são capazes de fornecer a densidade de conexões necessária ao enorme número de neurônios e sinapses. Neste sentido, este trabalho propõe DHyANA (Arquitetura Digital Neuromórfica Hierárquica), uma nova arquitetura em hardware para redes neurais pulsadas, a qual utiliza comunicação em rede-em-chip hierárquica. A arquitetura é otimizada para implementações de Máquinas de Estado Líquido. A arquitetura DHyANA foi exaustivamente testada em plataformas de simulação, bem como implementada em uma FPGA Stratix IV da Altera. Além disso, foi realizada a síntese lógica em tecnologia 65nm, a fim de melhor avaliar e comparar o sistema resultante com projetos similares, alcançando uma área de 0,23mm2 e potência de 147mW para uma implementação de 256 neurônios

DHyANA : uma arquitetura digital neuromórfica hierárquica para máquinas de estado líquido

Neural Networks has been a subject of research for at least sixty years. From the effectiveness in processing information to the amazing ability of tolerating faults, there are countless processing mechanisms in the brain that fascinates us. Thereupon, it comes with no surprise that as enabling technologies have become available, scientists and engineers have raised the efforts to understand, simulate and mimic parts of it. In a similar approach to that of the Human Genome Project, the quest for innovative technologies within the field has given birth to billion dollar projects and global efforts, what some call a global blossom of neuroscience research. Advances in hardware have made the simulation of millions or even billions of neurons possible. However, existing approaches cannot yet provide the even more dense interconnect for the massive number of neurons and synapses required. In this regard, this work proposes DHyANA (Digital HierArchical Neuromorphic Architecture), a new hardware architecture for a spiking neural network using hierarchical network-on-chip communication. The architecture is optimized for Liquid State Machine (LSM) implementations. DHyANA was exhaustively tested in simulation platforms, as well as implemented in an Altera Stratix IV FPGA. Furthermore, a logic synthesis analysis using 65-nm CMOS technology was performed in order to evaluate and better compare the resulting system with similar designs, achieving an area of 0.23mm2 and a power dissipation of 147mW for a 256 neurons implementation.Redes Neurais têm sido um tema de pesquisas por pelo menos sessenta anos. Desde a eficácia no processamento de informações à incrível capacidade de tolerar falhas, são incontáveis os mecanismos no cérebro que nos fascinam. Assim, não é nenhuma surpresa que, na medida que tecnologias facilitadoras tornam-se disponíveis, cientistas e engenheiros têm aumentado os esforços para o compreender e simular. Em uma abordagem semelhante à do Projeto Genoma Humano, a busca por tecnologias inovadoras na área deu origem a projetos internacionais que custam bilhões de dólares, o que alguns denominam o despertar global de pesquisa da neurociência. Avanços em hardware fizeram a simulação de milhões ou até bilhões de neurônios possível. No entanto, as abordagens existentes ainda não são capazes de fornecer a densidade de conexões necessária ao enorme número de neurônios e sinapses. Neste sentido, este trabalho propõe DHyANA (Arquitetura Digital Neuromórfica Hierárquica), uma nova arquitetura em hardware para redes neurais pulsadas, a qual utiliza comunicação em rede-em-chip hierárquica. A arquitetura é otimizada para implementações de Máquinas de Estado Líquido. A arquitetura DHyANA foi exaustivamente testada em plataformas de simulação, bem como implementada em uma FPGA Stratix IV da Altera. Além disso, foi realizada a síntese lógica em tecnologia 65nm, a fim de melhor avaliar e comparar o sistema resultante com projetos similares, alcançando uma área de 0,23mm2 e potência de 147mW para uma implementação de 256 neurônios

Conversion of synchronous artificial neural network to asynchronous spiking neural network using sigma-delta quantization

Artificial Neural Networks (ANNs) show great performance in several data analysis tasks including visual and auditory applications. However, direct implementation of these algorithms without considering the sparsity of data requires high processing power, consume vast amounts of energy and suffer from scalability issues. Inspired by biology, one of the methods which can reduce power consumption and allow scalability in the implementation of neural networks is asynchronous processing and communication by means of action potentials, so-called spikes. In this work, we use the well-known sigma-delta quantization method and introduce an easy and straightforward solution to convert an Artificial Neural Network to a Spiking Neural Network which can be implemented asynchronously in a neuromorphic platform. Briefly, we used asynchronous spikes to communicate the quantized output activations of the neurons. Despite the fact that our proposed mechanism is simple and applicable to a wide range of different ANNs, it outperforms the state-of-the-art implementations from the accuracy and energy consumption point of view. All source code for this project is available upon request for the academic purpose(1)

Perfil epidemiológico de hanseníase no sertão Pernambucano, Brasil / Epidemiological profile of hanseníase in sertão Pernambucano, Brazil

A Hanseníase é uma doença infecciosa crônica causada por Mycobacterium leprae, considerada um grave problema saúde pública mundial. O presente trabalho tem como objetivo traçar um perfil epidemiológico da Hanseníase no sertão pernambucano, tomando por base os dados eletrônicos do SINAN e DATASUS (ambos ligados ao Ministério da Saúde). A partir dessas fontes, realizou-se um estudo de série histórica observacional do tipo transversal dos casos notificados de Hanseníase entre os anos de 2006 a 2017. De acordo com os dados, observa-se que esse agravo apresentou um decréscimo no número de novos casos, na medida em que se constatava 43.642 casos no ano de 2006 contra 26.875 novos casos em 2017. Essa realidade, embora evidencie uma notável redução no número de novos casos de hanseníase, evoca a responsabilidade dos órgãos públicos de saúde no que tange à manutenção do controle desse agravo, assim como a criação de novas medidas que busquem a prevenção e a erradicação desse enfermo no território nacional.

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial

Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.13Hospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of Healt